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Screening for neurocognitive deficits in adult populations reliant on toxic cassava as the main source of food
Kabamba, Victor Hutu; Okitundu Luwa, Daniel; Mayambu Banea, Jean-Pierre; Giordani, Bruno; Boivin, Michael Joseph; Ngoyi, Dieudonné Mumba; Tshala-Katumbay, Désiré.
  • Kabamba, Victor Hutu; Department of Neurology, University of Kinshasa. Kinshasa. CD
  • Okitundu Luwa, Daniel; Department of Neurology, University of Kinshasa. Kinshasa. CD
  • Mayambu Banea, Jean-Pierre; Nutrition National Program & School of Public Health, Ministry of Health. Kinshasa. CD
  • Giordani, Bruno; Departments of Psychiatry, Neurology, and Psychology and School of Nursing. USA. US
  • Boivin, Michael Joseph; Department of Psychiatry and Neurology & Ophthalmology. Michigan State. US
  • Ngoyi, Dieudonné Mumba; Department of Tropical Medicine, University of Kinshasa & Institute National de Recherche Biomédicale. Kinshasa. CD
  • Tshala-Katumbay, Désiré; Department of Neurology, University of Kinshasa,. Department of Tropical Medicine, University of Kinshasa & Institute National de Recherche Biomédicale. Department of Neurology, Oregon Health & Science University. Kinshasa. CD
Ann. afr. méd. (En ligne) ; 16(2): 5031-5041, 2023. figures, tables
Article in English | AIM | ID: biblio-1425717
ABSTRACT
Context and objective. Chronic dietary reliance on improperly processed cyanogenic toxic cassava is widespread in sub-Saharan Africa. The objective of the present study was to screen for neurocognition impairments and daily-life functioning in adults with dietary dependency on cyanogenic cassava as the main source of food. Methods. A cross-sectional design enrolled heads of households (in couples) in the rural district of Kahemba, Democratic Republic of Congo. Participants were screened for neurocognitive impairments using the Community Screening Interview for Dementia (CSID). Detailed neuropsychiatric evaluations were performed and disease entities classified according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria when applicable. Cassava cyanogenic exposure was ascertained by urinary concentrations of thiocyanate (SCN). Regression models were used to identify predictors of CSID performance at the 0.05 significance level. Results. For hundred and six households (203 couples, mean age 38.4 ± 11. 4 years) were involved. One hundred thirty-six subjects (33.5 %) [69 women and 67 men, mean age 39 ± 14.4 years)] and 13 (3.2 %) [7 women and 6 men, mean age 32 ± 2.6 years] fulfilled the criteria for mild cognitive impairment (MCI) and Major Neurocognitive disorder (MNCD), respectively. The overall mean urinary concentration of SCN was 949.5+518.3 mol/l after adjusting Context and objective. Chronic dietary reliance on improperly processed cyanogenic toxic cassava is widespread in sub-Saharan Africa. The objective of the present study was to screen for neurocognition impairments and daily-life functioning in adults with dietary dependency on cyanogenic cassava as the main source of food. Methods. A cross-sectional design enrolled heads of households (in couples) in the rural district of Kahemba, Democratic Republic of Congo. Participants were screened for neurocognitive impairments using the Community Screening Interview for Dementia (CSID). Detailed neuropsychiatric evaluations were performed, and disease entities classified according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria when applicable. Cassava cyanogenic exposure was ascertained by urinary concentrations of thiocyanate (SCN). Regression models were used to identify predictors of CSID performance at the 0.05 significance level. Results. For hundred and six households (203 couples, mean age 38.4 ± 11. 4 years) were involved. One hundred thirty-six subjects (33.5 %) [69 women and 67 men, mean age 39 ± 14.4 years)] and 13 (3.2 %) [7 women and 6 men, mean age 32 ± 2.6 years] fulfilled the criteria for mild cognitive impairment (MCI) and Major Neurocognitive disorder (MNCD), respectively. The overall mean urinary concentration of SCN was . for age, gender, nutritional status, and history of konzo, neurocognition domain-specific deficits were independently associated with either hypertension or USCN (350mol / l incremental increase in excretion Functional impairments in daily-life activities increased as subjects poorly performed at the CSID screening (Spearman r = - .2, p < 0.01). Conclusion. Neurocognitive deficits in adults are common in Congolese adults relying on cyanogenic cassava as the main source of food. Our study findings warrant further studies to elucidate the overall lifespan brain/behavioral burden and mechanisms of cassava toxicity among adults with dietary dependency on cyanogenic cassava as the main source of food
Subject(s)

Full text: Available Index: AIM (Africa) Main subject: Starch and Fecula / Hypertension Type of study: Diagnostic study / Practice guideline / Prognostic study / Screening study Limits: Humans Language: English Journal: Ann. afr. méd. (En ligne) Year: 2023 Type: Article Institution/Affiliation country: Department of Neurology, University of Kinshasa,/CD / Department of Neurology, University of Kinshasa/CD / Department of Psychiatry and Neurology & Ophthalmology/US / Department of Tropical Medicine, University of Kinshasa & Institute National de Recherche Biomédicale/CD / Departments of Psychiatry, Neurology, and Psychology and School of Nursing/US / Nutrition National Program & School of Public Health, Ministry of Health/CD

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Full text: Available Index: AIM (Africa) Main subject: Starch and Fecula / Hypertension Type of study: Diagnostic study / Practice guideline / Prognostic study / Screening study Limits: Humans Language: English Journal: Ann. afr. méd. (En ligne) Year: 2023 Type: Article Institution/Affiliation country: Department of Neurology, University of Kinshasa,/CD / Department of Neurology, University of Kinshasa/CD / Department of Psychiatry and Neurology & Ophthalmology/US / Department of Tropical Medicine, University of Kinshasa & Institute National de Recherche Biomédicale/CD / Departments of Psychiatry, Neurology, and Psychology and School of Nursing/US / Nutrition National Program & School of Public Health, Ministry of Health/CD