Autophagy and anti-inflammation ameliorate diabetic neuropathy with Rilmenidine
Acta cir. bras
; 38: e387823, 2023. tab, graf, ilus
Article
in En
| LILACS, VETINDEX
| ID: biblio-1527591
Responsible library:
BR68.1
Localization: BR68.1
ABSTRACT
Purpose:
To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes induced by streptozotocin (STZ).Methods:
STZ (60 mg/kg) was administered to adult Sprague-Dawley rats to induce diabetes. On the 30th day after STZ administration, electromyography (EMG) and motor function tests confirmed the presence of DPN. Group 1 Control (n = 10), Group 2 DM + 0.1 mg/kg Rilmenidine (n = 10), and Group 3 DM + 0.2 mg/kg Rilmenidine (n = 10) were administered via oral lavage for four weeks. EMG, motor function test, biochemical analysis, and histological and immunohistochemical analysis of sciatic nerves were then performed.Results:
The administration of Rilmenidine to diabetic rats substantially reduced sciatic nerve inflammation and fibrosis and prevented electrophysiological alterations. Immunohistochemistry of sciatic nerves from saline-treated rats revealed increased perineural thickness, HMGB-1, tumor necrosis factor-α, and a decrease in nerve growth factor (NGF), LC-3. In contrast, Rilmendine significantly inhibited inflammation markers and prevented the reduction in NGF expression. In addition, Rilmenidine significantly decreased malondialdehyde and increased diabetic rats' total antioxidative capacity.Conclusions:
The findings of this study suggest that Rilmenidine may have therapeutic effects on DNP by modulating antioxidant and autophagic pathways.Key words
Full text:
1
Index:
LILACS
Main subject:
Autophagy
/
Diabetic Neuropathies
/
Rilmenidine
/
Anti-Inflammatory Agents
Type of study:
Prognostic_studies
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2023
Type:
Article