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Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil
Freitas, Nara Rubia de; Santana, Edna Braz Rocha de; Silva, Ágabo Macedo da Costa e; Silva, Sueli Meira da; Teles, Sheila Araújo; Gardinali, Noemi Rovaris; Pinto, Marcelo Alves; Martins, Regina Maria Bringel.
  • Freitas, Nara Rubia de; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Santana, Edna Braz Rocha de; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Silva, Ágabo Macedo da Costa e; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Silva, Sueli Meira da; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Teles, Sheila Araújo; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Gardinali, Noemi Rovaris; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Pinto, Marcelo Alves; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Martins, Regina Maria Bringel; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
Mem. Inst. Oswaldo Cruz ; 111(11): 692-696, Nov. 2016. tab
Article in English | LILACS | ID: biblio-829249
ABSTRACT
Hepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From April 2012 to October 2014, a cross-sectional study was conducted among 379 patients with acute non-A, non-B, non-C hepatitis in the City of Goiania, Central Brazil. Serum samples of all patients were tested for serological markers of HEV infection (anti-HEV IgM and IgG) by ELISA. Positive samples were confirmed using immunoblot test. Anti-HEV IgM and IgG positive samples were tested for HEV RNA. Of the 379 serum samples, one (0.3%) and 20 (5.3%) were positive for anti-HEV IgM and IgG, respectively. HEV RNA was not found in any sample positive for IgM and/or IgG anti-HEV. After multivariate analysis, low education level was independently associated with HEV seropositivity (p = 0.005), as well as living in rural area, with a borderline p-value (p = 0.056). In conclusion, HEV may be responsible for sporadic self-limited cases of acute hepatitis in Central Brazil.
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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis E virus / Hepatitis E Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Goiás/BR

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Full text: Available Index: LILACS (Americas) Main subject: Hepatitis E virus / Hepatitis E Type of study: Observational study / Prevalence study / Risk factors Limits: Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Goiás/BR