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Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
CHAHOUD, IBRAHIM; PAUMGARTTEM, FRANCISCO J R.
  • CHAHOUD, IBRAHIM; Charité - Universitätsmedizin Berlin. Institut für Klinische Pharmakologie und Toxikologie. Berlin. DE
  • PAUMGARTTEM, FRANCISCO J R; Charité - Universitätsmedizin Berlin. Institut für Klinische Pharmakologie und Toxikologie. Berlin. DE
An. acad. bras. ciênc ; 89(1,supl): 635-647, May. 2017. tab, graf
Article in English | LILACS | ID: biblio-886672
ABSTRACT
ABSTRACT The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter-strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI GD 9, 91/2 or 10; DBA/2J GD 10 or 101/2). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar -with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Skeleton / Teratogens / Somites / Embryonic Development / Embryo, Mammalian / Methylnitrosourea Limits: Animals / Pregnancy Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2017 Type: Article Affiliation country: Germany Institution/Affiliation country: Charité - Universitätsmedizin Berlin/DE

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Full text: Available Index: LILACS (Americas) Main subject: Skeleton / Teratogens / Somites / Embryonic Development / Embryo, Mammalian / Methylnitrosourea Limits: Animals / Pregnancy Language: English Journal: An. acad. bras. ciênc Journal subject: Science Year: 2017 Type: Article Affiliation country: Germany Institution/Affiliation country: Charité - Universitätsmedizin Berlin/DE