Huge recurrent gastric neuroendocrine tumor: a second-line chemotherapeutic dilemma
Autops. Case Rep
;
8(1): e2018005, Jan.-Mar. 2018. ilus
Article
in English
| LILACS
| ID: biblio-905466
ABSTRACT
Chemotherapy is considered "state of the art" for the treatment of poorly differentiated neuroendocrine neoplasms. Unfortunately, there is no standard effective post-first-line treatment for relapsing high-grade gastroenteropancreatic neuroendocrine neoplasms. We report the case of a patient with a gastric neuroendocrine carcinoma stage IV, with massive gastrointestinal bleeding at diagnosis. After the first line of platin-based chemotherapy a major tumoral response was documented, but the patient relapsed after 4 months. A second line of chemotherapy treatment was given, with the FOLFOX regimen, and the patient has been free of progression for almost 2 years. There is no second-line standard treatment accepted for this type of carcinoma, but 5-fluorouracil combined with oxaliplatin showed interesting antitumor activity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Organoplatinum Compounds
/
Stomach Neoplasms
/
Carcinoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Neuroendocrine Tumors
/
Fluorouracil
Limits:
Humans
/
Male
Language:
English
Journal:
Autops. Case Rep
Journal subject:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Year:
2018
Type:
Article
Affiliation country:
Portugal
/
Spain
Institution/Affiliation country:
Centro Hospitalar S. Joao/PT
/
Hospital Universitario Ramon y Cajal/ES
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