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Elastin increases biofilm and extracellular matrix production of Aspergillus fumigatus
Brandão, Ildnay de Souza Lima; Oliveira-Moraes, Heloiza Maria da Silva; Motta, Cristina Maria de Souza; Oliveira, Neiva Tinti de; Magalhães, Oliane Maria Correia.
  • Brandão, Ildnay de Souza Lima; Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Micologia. Cidade Universitária. BR
  • Oliveira-Moraes, Heloiza Maria da Silva; Universidade Federal de Pernambuco. Centro de Ciências Biológicas Rua Departamento de Micologia. Cidade Universitária. BR
  • Motta, Cristina Maria de Souza; Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Micologia. Pernambuco. BR
  • Oliveira, Neiva Tinti de; Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Micologia. Pernambuco. BR
  • Magalhães, Oliane Maria Correia; Universidade Federal de Pernambuco. Centro de Ciências Biológicas. Departamento de Micologia. Cidade Universitária. BR
Braz. j. microbiol ; 49(3): 675-682, July-Sept. 2018. graf
Article in English | LILACS | ID: biblio-951801
ABSTRACT
Abstract Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of elastin on the production and development of the biofilm of A. fumigatus. In RPMI containing 10 mg/mL of elastin, a significant increase (absorbance p < 0.0001; dry weight p < 0.0001) in the production of biofilm was observed in comparison to when RPMI was used alone, reaching a maximum growth of 18.8 mg (dry weight) of biofilm in 72 h. In addition, elastin stimulates the production (p = 0.0042) of extracellular matrix (ECM) and decreases (p = 0.005) the hydrophobicity during the development of the biofilm. These results suggest that elastin plays an important role in the growth of A. fumigatus and that it participates in the formation of thick biofilm.
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Full text: Available Index: LILACS (Americas) Main subject: Aspergillosis / Aspergillus fumigatus / Elastin / Biofilms / Extracellular Matrix Limits: Humans Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR

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Full text: Available Index: LILACS (Americas) Main subject: Aspergillosis / Aspergillus fumigatus / Elastin / Biofilms / Extracellular Matrix Limits: Humans Language: English Journal: Braz. j. microbiol Journal subject: Microbiology Year: 2018 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de Pernambuco/BR