[Epigenetic application in the breast cancer]

ABSTRACT

With 1 million new cases causing 375000 deaths worldwide per year, breast cancer is the leading cause of cancer death in women in both developing and developed countries. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. Epigenetic refers to the cellular information of transcription memory which is transmitted through cell divisions but is not sequence based. Epigenetic is the connecting circle of the genotype and the environment. Which connect the inheritable gene transcription pattern and phenotype of a cell. DNA promoter methylation and chromatin remodeling are two main mechanisms of epigenetic modifications which are emerging as targets for breast cancer detection, prognosis and treatment. Because of their potential for reversal, epigenetic alterations are considered to be promising in caner treatment and epidrug production. Therapeutics that target methylation and histone modifications in breast cancer already exist. Advances in epidrugs are likely to play important role in future of cancer treatment