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introduction to RNA interference [RNAi]
Genetics in the 3rd Millennium. 2005; 2 (4): 469-476
in English | IMEMR | ID: emr-172122
ABSTRACT
The discovery of RNA interference [RNAi] in recent years has revolutionised biological and medical research. RNAi is the sequence-specific gene silencing triggered by double-stranded RNA [dsRNA]. Until a couple of years ago only biologists working with Caenorhabditis elegans and plants could use RNAi technology to gain insight into gene function. Tuschl and colleagues in 2001 showed that RNAi could also be used in mammalian cells to effectively inhibit endogenous gene expression in a sequence-specific manner. This remarkable work created high hopes of using RNAi as a potential therapy for many human diseases. Currently RNAi is widely used for functional genomics and for specific therapeutic intervention in preclinical models of different human diseases characterised by aberrant gene expression. This review provides an overview to the development of RNAi technology and its current applications in medicine
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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Genet. in the 3rd Millenium Year: 2005

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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Genet. in the 3rd Millenium Year: 2005