Effect of removal of spermatogonial stem cells [SSCs] from in vitro culture on gene expression of niche factors in bovine

ABSTRACT

Background: Niche cells, regulating Spermatogonial Stem Cells [SSCs] fate are believedto have a reciprocal communication with SSCs. The present study was conductedto evaluate the effect of SSC elimination on the gene expression of Glial cell line-Derived Neurotrophic Factor [GDNF], Fibroblast Growth Factor 2 [FGF2] and KitLigand [KITLG], which are the main growth factors regulating SSCs development andsecreted by niche cells, primarily Sertoli cells