[Investigating the stability of polymer coating of methoxy polyethylene glycol activated by succinimidyl valerate on the surface of red blood cells under in vitro and in vivo conditions]

ABSTRACT

Objective: The host immune response against minor donor blood groups may be considered a significant problem in certain groups of patients that undergo transfusions such as those who require repeat transfusions [thalassemia]. A proposed solution is to coat the surface antigens on red blood cells [RBCs] by covalent binding of methoxy polyethylene glycol [mPEG]. This study aims to determine the storage time of PEGylated cells before injection and its effective time during in vivo conditions