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Methylation status of H19/IGF2 differentially methylated region in in vitro human blastocysts donated by healthy couples
IBJ-Iranian Biomedical Journal. 2017; 21 (1): 16-23
in English | IMEMR | ID: emr-185663
ABSTRACT
Backgrund Imprinted genes are a unique subset of few genes, which have been differentially methylated region [DMR] in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. Several studies have shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception micro-environments often is occurred by assisted reproduction techniques [ART]. This study investigated the methylation status of H19/IGF2 DMR at high-quality expanding/expanded human blastocysts donated by healthy individuals to evaluate the risks linked to ART
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Index: IMEMR (Eastern Mediterranean) Main subject: Blastocyst / In Vitro Techniques / Genomic Imprinting / CpG Islands / Reproductive Techniques, Assisted / Epigenesis, Genetic / Iran Limits: Animals / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Iran. Biomed. J. Year: 2017

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Index: IMEMR (Eastern Mediterranean) Main subject: Blastocyst / In Vitro Techniques / Genomic Imprinting / CpG Islands / Reproductive Techniques, Assisted / Epigenesis, Genetic / Iran Limits: Animals / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Iran. Biomed. J. Year: 2017