Methylation status of H19/IGF2 differentially methylated region in in vitro human blastocysts donated by healthy couples
IBJ-Iranian Biomedical Journal. 2017; 21 (1): 16-23
in English
| IMEMR
| ID: emr-185663
ABSTRACT
Backgrund Imprinted genes are a unique subset of few genes, which have been differentially methylated region [DMR] in a parental origin-dependent manner during gametogenesis, and these genes are highly protected during pre-implantation epigenetic reprogramming. Several studies have shown that the particular vulnerability of imprinting genes during suboptimal pre- and peri-conception micro-environments often is occurred by assisted reproduction techniques [ART]. This study investigated the methylation status of H19/IGF2 DMR at high-quality expanding/expanded human blastocysts donated by healthy individuals to evaluate the risks linked to ART
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Blastocyst
/
In Vitro Techniques
/
Genomic Imprinting
/
CpG Islands
/
Reproductive Techniques, Assisted
/
Epigenesis, Genetic
/
Iran
Limits:
Animals
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Iran. Biomed. J.
Year:
2017
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