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Traumatic brain injury research and expression of caveolin-1 and its relationship with disease prognosis
Pakistan Journal of Pharmaceutical Sciences. 2017; 30 (Supp. 3): 997-1000
in English | IMEMR | ID: emr-188084
ABSTRACT
The objective of this paper is to study the expression of caveolin-1 in the traumatic brain injury patients and its relationship with disease prognosis. Caveolin-1 was measured in 52 patients with ventricular hemorrhage within 8h, 24h, 48h, 72h and 1 week after onset by enzyme-linked immunosorbent assay [ELISA], to observe the changes of cerebrospinal fluid caveolin-1. The level of caveolin-1 in the brain of all patients was higher than that of the control group at 8 h, 24h, 48 h, 72h and 1 weeks after the onset [P<0.05] and the level of caveolin-1 in cerebrospinal fluid [CSF] of the severe group was higher than that of the light-medium group within 8h, 24h, 48 h and 72h after the onset [P<0.05]. The level of caveolin-1 in CSF was significantly increased in patients with ventricular hemorrhage within 8h, 24h, 48h, 72h and 1 weeks after onset, and the expression of caveolin-1 in brain was related to the severity of craniocerebral injury. Therefore, the expression of caveolin-1 can be used as an indicator of the prognosis of traumatic brain injury disease
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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Pak. J. Pharm. Sci. Year: 2017

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Index: IMEMR (Eastern Mediterranean) Language: English Journal: Pak. J. Pharm. Sci. Year: 2017