Introducing a new experimental islet transplantation model using biomimetic hydrogel and a simple high yield islet isolation technique

ABSTRACT

Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus [T1DM]. This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functional islets and transplantation are crucial