Effects of bone marrow mesenchymal stem cells-conditioned medium on tibial partial osteotomy model of fracture healing in hypothyroidism rats

Niloofar, Sefati; Mohsen, Norouzian; Hojjat Allah, Abbaszadeh; Mohammad Amin, Abdollahifar; Abdollah, Amini; Mohammad, Bagheri; Arefeh, Aryan; Fatemeh, Fathabady

Niloofar, Sefati; Mohsen, Norouzian; Hojjat Allah, Abbaszadeh; Mohammad Amin, Abdollahifar; Abdollah, Amini; Mohammad, Bagheri; Arefeh, Aryan; Fatemeh, Fathabady.

IBJ-Iranian Biomedical Journal. 2018; 22 (2): 90-98

in English | IMEMR | ID: emr-192455

ABSTRACT

ABSTRACT

Background:

Hypothyroidism is associated with dysfunction of the bone turnover with reduced osteoblastic bone formation and osteoclastic bone resorption. Mesenchymal stem cells [MSCs] secrete various factors and cytokines that may stimulate bone regeneration. The aim of this study was to determine the effects of MSCs-conditioned medium [CM] in hypothyroidism male rats after inducing bone defect

Subject(s)

Animals, Laboratory; Culture Media, Conditioned; Hypothyroidism/veterinary; Osteotomy; Tibial Fractures; Fracture Healing

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Index: IMEMR (Eastern Mediterranean) Main subject: Osteotomy / Tibial Fractures / Fracture Healing / Culture Media, Conditioned / Hypothyroidism Limits: Animals Language: English Journal: Iran. Biomed. J. Year: 2018

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