Nanocurcumin-mediated down-regulation of telomerase via stimulating TGF beta 1 signaling pathway in hepatocellular carcinoma cells
IBJ-Iranian Biomedical Journal. 2018; 22 (3): 171-179
in English
| IMEMR
| ID: emr-192466
ABSTRACT
Background:
Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and transforming growth factor- beta 1 [TGF beta 1] has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGF beta 1 pathway in a hepatocellular carcinoma cell line [Huh7]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Gene Expression
/
Telomerase
/
Curcumin
/
Transforming Growth Factor beta1
/
Liver Neoplasms
Limits:
Animals
Language:
English
Journal:
Iran. Biomed. J.
Year:
2018
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