Potential and mechanism of A-Tab as a controlled release agent
Mansoura Journal of Pharmaceutical Sciences. 1998; 14 (1): 71-87
in English
| IMEMR
| ID: emr-48634
ABSTRACT
This study investigated the mechanism by which anhydrous calcium phosphate [A-TAB] exhibits its sustained release matrix, via premixing of A-TAB [diluent] powder with different excipients, e.g. Avicel, sodium alginate and polyvinyl alcohol [PVA], to block entrapment sites if any, on the dissolution of theophylline from A-TAB tablets. Furthermore, the inclusion of other excipient [palmetic acid] to impart a more acid resistant character on the diluent/drug blend and thus assist in maintaining the matrix structure of A-TAB were also investigated. The rate and extent of drug dissolution were dependent on the order of mixing of A-TAB with the drug and excipient as well as the pH of the dissolution medium
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Palmitic Acids
/
Polyvinyl Alcohol
/
Theophylline
/
Calcium Phosphates
/
Drug Design
/
Delayed-Action Preparations
Language:
English
Journal:
Mansoura J. Pharm. Sci.
Year:
1998
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