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Rheumatic disorders in virus-C hepatitis patients
Egyptian Rheumatology and Rehabilitation. 2001; 28 (2): 445-456
in English | IMEMR | ID: emr-56761
ABSTRACT
To study the incidence of rheumatologic disorders in chronic hepatitis C infection. Fifty patients suffering from chronic hepatitis C [Positive HCV antibody and PCR] of more than six months duration were included in the study. Another group of twenty-five patients with rheumatic manifestations free of HCV served as a control group. They were identical in gender and age. Among the HCV patients group cryoglobulinaemia was detected in 29 cases [58%], antinuclear antibodies in 1 0 cases [20%] rheumatoid factor in 19 cases [38%], hypocomplementaemia in 20 cases [40%], myalgia in 24 cases [48%], arthralgia in 26 cases [52%] arthritis in 18 cases [36%] enthesitis in 39 cases [78%], fatigability in 46 cases [92%], Raynaud's Phenomenon in 14 cases [28%], xerophthaimia in 1 0 cases [20%], rash in 29 cases [58%], carpal tunnel syndrome in 6 cases [1 2%] and R A in 6 cases [1 2%]. HCV may play a role in the pathogenosis of these auto immune phenomena. This hypothesis is mainly based on the lymphotropism of HCV that can be responsible for a chronic activation of both T and B lymphocytes, leading to complex immune system disorders. But more studies are required to define the extent of this role
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Index: IMEMR (Eastern Mediterranean) Main subject: Rheumatoid Factor / Complement C3 / Cryoglobulins / Antibodies, Antinuclear / Rheumatic Diseases / Incidence / Immune Complex Diseases / Hepatitis C Antibodies / Liver Function Tests Type of study: Incidence study Limits: Female / Humans / Male Language: English Journal: Egypt. Rheumatol. Rehabil. Year: 2001

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Index: IMEMR (Eastern Mediterranean) Main subject: Rheumatoid Factor / Complement C3 / Cryoglobulins / Antibodies, Antinuclear / Rheumatic Diseases / Incidence / Immune Complex Diseases / Hepatitis C Antibodies / Liver Function Tests Type of study: Incidence study Limits: Female / Humans / Male Language: English Journal: Egypt. Rheumatol. Rehabil. Year: 2001