Los genes de la hipertensión arterial humana / The genes of human arterial hypertension
Rev. méd. Chile
; 125(3): 351-7, mar. 1997. tab, ilus
Article
in Es
| LILACS
| ID: lil-194840
Responsible library:
CL1.1
ABSTRACT
In the last decade, two types of genes participating in the etiology of hypertension have been identified. The primary genes or blood pressure regulators are those that codify enzymes (renin, kallikrein, kininase, aminopeptidase), hormones (angiotensins, vasopressin, aldosterone, prostaglandins and atrial natriuretic peptide) and substrates (angiotensinogen and kininogen). They cause arteriolar vasodilation or vasoconstriction or sodium retention in the extravascular space. Allelic polymorphisms associated to essential hypertension have been described. The secondary genes are those that produce hereditary diseases of low prevalence, associated to hypertension in 20 to 80 percent of patients (polycystic kidney disease, pheochromocytoma, adrenal hyperplasia, hereditary nephritis). Forty genes located in all chromosomes, that are dominantly, recessively or X-linked transmitted, have thus far been idenfied. Chromosomal maps with all genic loci are presented
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Index:
LILACS
Main subject:
Genome
/
Hypertension
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
1997
Type:
Article