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A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
Mem. Inst. Oswaldo Cruz ; 92(supl.2): 193-6, Dec. 1997. tab, graf
Article in English | LILACS | ID: lil-202031
ABSTRACT
The elevation of intercellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibit eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recuitment is both a sensitive and simple tool to test the efficacy of PDE4 inhibitors in vivo.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Phosphodiesterase Inhibitors / Eosinophils Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 1997 Type: Article / Congress and conference

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Full text: Available Index: LILACS (Americas) Main subject: Phosphodiesterase Inhibitors / Eosinophils Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 1997 Type: Article / Congress and conference