Susceptibility of Colombian Plasmodium falciparum isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro
Mem. Inst. Oswaldo Cruz
; 101(3): 341-344, May 2006.
Article
in En
| LILACS
| ID: lil-431738
Responsible library:
BR1.1
ABSTRACT
There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P. falciparum strains to AQ and N-desethylamodiaquine is used to illustrate the need to standardized methodologies and compare inhibitory concentrations, instead of resistant/susceptible phenotypes, when studying the mechanisms of resistance to AQ and monitoring drug susceptibility trends in the field.
Full text:
1
Index:
LILACS
Main subject:
Plasmodium falciparum
/
Aminoquinolines
/
Amodiaquine
/
Antimalarials
Limits:
Animals
Country/Region as subject:
America do sul
/
Colombia
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2006
Type:
Article
/
Project document