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Células endoteliais circulantes, progenitoras endoteliais e micropartículas / Circulating endothelial cells, endothelial progenitor cells and microparticles
França, Carolina Nunes; Fonseca, Francisco Antonio Helfenstein; Izar, Maria Cristina de Oliveira.
  • França, Carolina Nunes; Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo. BR
  • Fonseca, Francisco Antonio Helfenstein; Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo. BR
  • Izar, Maria Cristina de Oliveira; Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo. BR
Rev. Soc. Cardiol. Estado de Säo Paulo ; 20(2): 158-165, abr.-jun. 2010. ilus
Article in Portuguese | LILACS | ID: lil-570202
RESUMO
A disfunção endotelial está associada ao desenvolvimento e às complicações da aterosclerose e pode ser um marcador do risco cardiovascular. Em situação fisiológica, ocorre equilíbrio entre a erosão da monocamada de células endoteliais e a capacidade de reposição dessas células para a manutenção da homeostase vascular; porém, quando a perda do endotélio, quer por erosão quer por apoptose, superar a capacidade de reposição celular ou se as células endoteliais não preservarem suas propriedades características, ocorre disfunção endotelial. Biomarcadores de função endotelial prompreendem características das células endotelial que possam ser mensuradas. Entre os novos biomarcadores da função endotelial, um grupo de marcadores do turnover dessas células tem sido proposto células progenitoras endoteliais, células endoteliais circulantes e micropartículas de diferentes populações celulares, células progenitoras endoteliais, células endoteliais circulantes e micropartículas oferecem um meio não-invasivo para estimar a competência vascular. Níveis de células progenitoras endoteliais podem aumentar em eventos agudos, como o infarto...
ABSTRACT
Endothelial dysfunction is associated with the development of atherosclerosis complications and may be a marker of cardiovascular risk. In physiological conditions there is a balance between the erosion of the endothelial cell monolayer and the ability of the regenerated endothelium to maintain vascular homeostasis; however, when there is loss of endothelial cells, due to erosion or to apoptosis, surpassing the capacity of endothelial regrowth, or if these cells do not preserve their protective characteristics, the endothelium becomes dysfunctional. Endothelial function biomarkers comprise measurable characteristics of endothelial cells. Among new biomarkers of endothelial function, a group of markers of the turnover of these cells has been proposed endothelial progenitor cells, circulating endothelial cells, and microparticles of different cell populations. As mediators of endothelial homeostasis, endothelial progenitor cells, circulating endothelial cells and microparticles are non-invasive means to estimate vascular competence. Endothelial progenitor cell levels may increase in acute events, such as in acute myocardial infarction or in vascular injury. However, cardiovascular risk factors reduce the number of endothelial progenitor cells. Microparticles are small fragments released by activated or apoptotic cells (endothelial cells, platelets, etc.) found in healthy individuals and among those with cardiovascular diseases. Platelets are the cells that release the greatest amount of microparticles in the blood, although other cell populations also produce microparticles. Higher levels of endothelial microparticles have been found in acute coronary syndrome, peripheral arterial disease and in patients with cardiovascular risk factors...
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Index: LILACS (Americas) Main subject: Bone Marrow / Endothelial Cells / Endothelium / Atherosclerosis Type of study: Etiology study / Risk factors Limits: Humans Language: Portuguese Journal: Rev. Soc. Cardiol. Estado de Säo Paulo Journal subject: Cardiology Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR

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Index: LILACS (Americas) Main subject: Bone Marrow / Endothelial Cells / Endothelium / Atherosclerosis Type of study: Etiology study / Risk factors Limits: Humans Language: Portuguese Journal: Rev. Soc. Cardiol. Estado de Säo Paulo Journal subject: Cardiology Year: 2010 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal de São Paulo/BR