Effect of prenatal low-protein diet in subepicardial neuron of rat: a morphological study
Braz. j. morphol. sci
; 27(2): 82-87, Apr.-June 2010. ilus
Article
in En
| LILACS
| ID: lil-644222
Responsible library:
BR734.1
ABSTRACT
Heart autonomic ganglia are known to play an important role in cardiac rhythm control, protecting againstcertain arrhythmias due to their parasympathetic activity. Cardiac disorders may arise following starvingstates during pregnancy; cardiac performance and cardiac fibers have been shown to suffer deleterious effectsunder starvation. Morphology of these plexuses may suffer interference of extrinsic factors, but data is stilllacking about the effects of low protein diet during pregnancy and early postnatal period on subepicardialneuron structure. Two groups of pregnant Wistar rats were submitted to different diets according to itsprotein content, normal and 5% casein, until 21 days after delivery. The offspring was divided in two groups,D and N, according to their motherLs diet, low and normal protein respectively, and then sacrificed. Theatrial neurons were identified by À-nicotinamide adenine dinucleotide (NADH) and adenine dinucleotidephosphate diaphorase (NADPH-d) staining. Profile areas of the nerve cell bodies were measured. NADHstaining did not show significant differences between groups but NADPH- d profile areas of nerve cell bodiesfrom group D were smaller than in control group. Ultrastructural changes were observed in group D ratsagglomerated ribosomes, increase in nucleoli density and irregular chromatin.Low-protein diet in rats at earlydevelopmental stages interferes in size, and ultrastructure of subepicardial neurons. Even though underfeedingduring perinatal period did not produce neuronal death, neuron development is delayed and permanentchanges can supervene in long term.
Key words
Full text:
1
Index:
LILACS
Main subject:
Arrhythmias, Cardiac
/
Ribosomes
/
Diet, Protein-Restricted
/
Malnutrition
/
Ganglia
/
Neurons
Type of study:
Prognostic_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Braz. j. morphol. sci
Journal subject:
ANATOMIA
Year:
2011
Type:
Article