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PTK2 and PTPN11 expression in myelodysplastic syndromes
Lazarini, Mariana; Machado-Neto, Joao Agostinho; Archangelo, Leticia Frohlich; Mendes-Silva, Bruna Fernandes; Bigarella, Carolina Louzao; Traina, Fabiola; Saad, Sara Teresinha Olalla.
  • Lazarini, Mariana; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
  • Machado-Neto, Joao Agostinho; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
  • Archangelo, Leticia Frohlich; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
  • Mendes-Silva, Bruna Fernandes; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
  • Bigarella, Carolina Louzao; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
  • Traina, Fabiola; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
  • Saad, Sara Teresinha Olalla; Hematology and Hemotherapy Center-University of Campinas/Hemocentro-Unicamp. Instituto Nacional de Ciencia e Tecnologia do Sangue. Campinas. BR
Clinics ; 68(10): 1371-1375, out. 2013. tab, graf
Article in English | LILACS | ID: lil-689980
ABSTRACT

OBJECTIVE:

The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes.

METHODS:

Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors.

RESULTS:

Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells.

CONCLUSIONS:

Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors. .
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Myelodysplastic Syndromes / Bone Marrow Cells Type of study: Etiology study / Evaluation studies / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hemocentro-Unicamp+BR

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Full text: Available Index: LILACS (Americas) Main subject: Myelodysplastic Syndromes / Bone Marrow Cells Type of study: Etiology study / Evaluation studies / Prognostic study / Risk factors Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Clinics Journal subject: Medicine Year: 2013 Type: Article Affiliation country: Brazil Institution/Affiliation country: Hemocentro-Unicamp+BR