Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation
Acta cir. bras
;
29(7): 457-464, 07/2014. tab, graf
Article
in English
| LILACS
| ID: lil-714576
ABSTRACT
PURPOSE:
To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations.METHODS:
Thirty five female rats were divided into three groups G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers.RESULTS:
The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group.CONCLUSION:
Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea. .
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Urethra
/
Urodynamics
/
Urinary Bladder
/
Diabetes Mellitus, Experimental
Type of study:
Etiology study
/
Evaluation studies
Limits:
Animals
Language:
English
Journal:
Acta cir. bras
Journal subject:
General Surgery
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2014
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Sao Paulo/BR
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