Nuevas proyecciones fisiológicas, patológicas y terapéuticas de la leptina / Novel physiological and therapeutic implications of leptin
Rev. méd. Chile
; 142(6): 738-747, jun. 2014. ilus
Article
in Es
| LILACS
| ID: lil-722924
Responsible library:
CL1.1
ABSTRACT
The adipose tissue is an endocrine organ that produces a variety of protein hormones. One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Acting at a local level, leptin modulates the immune system and promotes liver fibrogenesis. The most promising therapeutic implications of leptin will possibly be in type 1 diabetes mellitus (DM1). Its supplementation in animal models of DM1 prevents hyperglycemia and ketoacidosis. These actions depend on the activation of leptin receptors in the central nervous system and the suppression of glucagon signaling in the liver.
Key words
Full text:
1
Index:
LILACS
Main subject:
Leptin
Limits:
Animals
/
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2014
Type:
Article