Calcium-osmolality interaction in the inotropic response of isolated rat atria to increased sodium concentration
Braz. j. med. biol. res
; 22(6): 807-10, June 1989. ilus
Article
in En
| LILACS
| ID: lil-75248
Responsible library:
BR26.1
ABSTRACT
The effects of osmolality (300 and 450 mOsm/l) and external calcium concentration ([Ca2 +]o 0.87, 1.13, 1.47 and 1.92 mM) on the inotropic response of isolated rat left atria to an increase of 97.8 mM in extracellular sodium concentration ([Na + ]o) were studied. The evoked tensions developed during 30 min after the exposure to increased [Na + ]o increased with increasing [Ca2 +]o. In iso-osmotic solutions, tension was lower than in hyperosmotic solutions when [Ca2+]o was 0.87 and 1.13 mM, but not for higher [Ca2+]o, revealing a Ca2 -osmolality interaction in the determination of the inotropic response
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Index:
LILACS
Main subject:
Sodium
/
Calcium
/
Myocardial Contraction
Limits:
Animals
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1989
Type:
Article
/
Congress and conference
/
Project document