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Changes in mast cell infiltration: a possible mechanism in detrusor overactivity induced by visceral hypersensitivity
Zhang, Nian-zhao; Ma, Lin; Jun, Chen; Guo, Yan-xia; Yuan, Hui-qing.
  • Zhang, Nian-zhao; Shandong University. Qilu Hospital. Department of Urology. Jinan. CN
  • Ma, Lin; Shandong University. Qilu Hospital. Department of Urology. Jinan. CN
  • Jun, Chen; Shandong University. Qilu Hospital. Department of Urology. Jinan. CN
  • Guo, Yan-xia; Shandong University. Qilu Hospital. Department of Urology. Jinan. CN
  • Yuan, Hui-qing; Shandong University. Qilu Hospital. Department of Urology. Jinan. CN
Int. braz. j. urol ; 42(2): 373-382, Mar.-Apr. 2016. tab, graf
Article in English | LILACS | ID: lil-782845
ABSTRACT
ABSTRACT

Objective:

To establish the detrusor overactivity (DO) model induced by visceral hypersensitivity (VH) and investigate the relationship between mast cell (MC) infiltration and DO. Materials and

Methods:

Sixty rats are divided into 4 groups randomly Group 1Baseline group; Group 2 DO group; Group 3 CON group; Group 4 VH group. The colorectal distension (CRD) and abdominal withdral reflex (AWR) scores are performed to evaluate VH. The cystometric investigation and histological test of MC infiltration are assessed.

Results:

The threshold pressure of CRD in the VH group is significantly lower than that in the CON group (P<0.001). At the distension pressure ≥20 mmHg, the AWR scores of the VH group are significantly higher than those of the CON group (10 mmHg P=0.33; 20 mmHg P=0.028; 40 mmHg P<0.001; 60 mmHg P<0.001; 80 mmHg P<0.001). DO model is successfully established in the VH group (DO rate=100%). Compared with the CON group, the numbers of MC infiltration are significantly increased in the VH group, including submucosa of bladder (P<0.001), mucosa lamina propria/mesentery of small intestine (P<0.001), and mucosa lamina propria/mesentery of large intestine (P<0.001). Furthermore, more MC activation as well as degranulation are observed in the VH group.

Conclusions:

It is indicated that DO model can be established in the VH rats. The MC infiltration may play an important role in DO induced by VH, and may be helpful to understand the mechanisms of DO in VH patients.
Subject(s)


Full text: Available Index: LILACS (Americas) Main subject: Viscera / Disease Models, Animal / Urinary Bladder, Overactive / Hypersensitivity / Mast Cells Type of study: Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Shandong University/CN

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Full text: Available Index: LILACS (Americas) Main subject: Viscera / Disease Models, Animal / Urinary Bladder, Overactive / Hypersensitivity / Mast Cells Type of study: Prognostic study Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2016 Type: Article Affiliation country: China Institution/Affiliation country: Shandong University/CN