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Hepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazil
Passos-Castilho, Ana Maria; de Sena, Anne; Domingues, Ana Lucia Coutinho; Lopes-Neto, Edmundo Pessoa; Medeiros, Tibério Batista; Granato, Celso Francisco Hernandez; Ferraz, Maria Lúcia.
  • Passos-Castilho, Ana Maria; Unifesp. Division of Infectious Diseases. São Paulo. BR
  • de Sena, Anne; Unifesp. Division of Infectious Diseases. São Paulo. BR
  • Domingues, Ana Lucia Coutinho; Unifesp. Division of Infectious Diseases. São Paulo. BR
  • Lopes-Neto, Edmundo Pessoa; Unifesp. Division of Infectious Diseases. São Paulo. BR
  • Medeiros, Tibério Batista; Unifesp. Division of Infectious Diseases. São Paulo. BR
  • Granato, Celso Francisco Hernandez; Unifesp. Division of Infectious Diseases. São Paulo. BR
  • Ferraz, Maria Lúcia; Unifesp. Division of Infectious Diseases. São Paulo. BR
Braz. j. infect. dis ; 20(3): 262-266, May.-June 2016. tab
Article in English | LILACS | ID: lil-789476
ABSTRACT
Abstract Background Hepatitis E virus (HEV) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. HEV seroprevalence in patients with Schistosoma mansoni in Brazil is unknown. We evaluated the prevalence of past or present HEV infection in schistosomiasis patients in Recife, Pernambuco, Brazil. A total of 80 patients with Schistosoma mansoni were consecutively enrolled in a cross-sectional study. Serum samples were tested for the presence of anti-HEV IgG antibodies by enzyme immunoassay (Wantai anti-HEV IgG, Beijing, China) and for the presence of HEV RNA using real time reverse transcriptase-polymerase chain reaction with primers targeting the HEV ORF2 and ORF3. Clinical and laboratory tests as well as abdominal ultrasound were performed at the same day of blood collection. Results Anti-HEV IgG was positive in 18.8% (15/80) of patients with SM. None of the samples tested positive for anti-HEV IgM or HEV-RNA. Patients with anti-HEV IgG positive presented higher levels of alanine aminotranferase (p = 0.048) and gama-glutamil transferase (p = 0.022) when compared to patients without anti-HEV IgG antibodies. Conclusion This study demonstrates that the seroprevalence of HEV is high in patients with Schistosoma mansoni in Northeastern of Brazil. Past HEV infection is associated with higher frequency of liver enzymes abnormalities. HEV infection and its role on the severity of liver disease should be further investigated among patients with Schistosoma mansoni.
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Full text: Available Index: LILACS (Americas) Main subject: Schistosomiasis mansoni / Hepatitis E virus / Hepatitis E Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Limits: Animals / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Unifesp/BR

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Full text: Available Index: LILACS (Americas) Main subject: Schistosomiasis mansoni / Hepatitis E virus / Hepatitis E Type of study: Diagnostic study / Observational study / Prevalence study / Risk factors Limits: Animals / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2016 Type: Article Affiliation country: Brazil Institution/Affiliation country: Unifesp/BR