Hypertrophic cardiomyopathy: an autopsy analysis of 14 cases.
J Postgrad Med
;
2001 Jul-Sep; 47(3): 165-70
Article
in English
| IMSEAR
| ID: sea-117762
ABSTRACT
BACKGROUND:
Hypertrophic cardiomyopathy (HCM) is one of the less common forms of primary cardiomyopathies. There is little data available on HCM in Indian literature.AIMS:
To assess the incidence and analyse the clinicopathological features of HCM. SETTINGS Analysis of data of 15 years from a tertiary care centre. METHODS ANDMATERIAL:
The clinical and pathological data in fourteen cases of HCM with respect to their gross and microscopic features and clinical presentation were reviewed.RESULTS:
Incidence of HCM amongst the autopsied primary cardiomyopathies (N = 101) was 13.9% (n=14). Males were affected more. Common presenting symptoms were exertional dyspnoea, angina and palpitations. Concentric and asymmetric hypertrophy was equally seen. Obliterative small vessel disease was noted in 50% of the cases. Although significant myofibre disarray (>5%) was seen in all fourteen cases, it could be demonstrated in only 40- 50% of an average of twenty sections studied. Type IA myofibre disarray was the commonest. Six of the fourteen patients died suddenly. Cardiac failure was the commonest cause of death.CONCLUSIONS:
Myofibre disarray is a highly sensitive and specific marker for HCM only when considered in a quantitative rather than a qualitative fashion. In this context, the rationale for performing endomyocardial biopsy is to rule out mimics of HCM.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Autopsy
/
Cardiomyopathy, Hypertrophic
/
Aged
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Death, Sudden, Cardiac
/
Adult
Type of study:
Qualitative research
Language:
English
Journal:
J Postgrad Med
Year:
2001
Type:
Article
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