Comparison of effects of mass annual and biannual single dose therapy with diethylcarbamazine for the control of Malayan filariasis.
Southeast Asian J Trop Med Public Health
;
1991 Sep; 22(3): 402-11
Article
in English
| IMSEAR
| ID: sea-34513
ABSTRACT
Annual and biannual mass single dose diethylcarbamazine citrate (DEC) at 6 mg/kg body weight was administered to people in a Brugia malayi endemic area in Shertallai part of Kerala, India, in 1987 and 1988. The coverage of population ranged between 41.33% and 66.01% in different rounds. The highest percentage of treated population developing side reactions was 8.4%. Both annual and biannual regimens were effective in reducing the microfilaria prevalence significantly from 4.90% to 1.23% and from 6.27% to 0.62% respectively and the incidence of infection was minimal in the adult population and zero among children. There was significant reduction in mean microfilaria count in both annual (81.08%) and biannual (98.00%) areas. Marked reduction in the proportion of high density carriers and infectivity index of the population after DEC therapy was also observed. Beneficial effect of mass single dose DEC on clinical cases of filariasis was evident from the reduction in the prevalence of acute manifestations, recent edema cases and the proportion of chronic cases with acute episodes. Results obtained from mass treatment areas were compared with those of the control area.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Drug Administration Schedule
/
Child
/
Child, Preschool
/
Mass Screening
/
Incidence
/
Prevalence
/
Adolescent
/
Adult
/
Diethylcarbamazine
Type of study:
Incidence study
/
Prevalence study
/
Prognostic study
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
Southeast Asian J Trop Med Public Health
Year:
1991
Type:
Article
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