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Increased circulating CCR3+ type 2 helper T cells in house dust mite-sensitive Chinese patients with allergic diseases.
Asian Pac J Allergy Immunol ; 2003 Dec; 21(4): 205-10
Article in English | IMSEAR | ID: sea-37012
ABSTRACT
Chemokine receptor expression has been shown to be associated with the differentiation of T helper cells. The CCR3, CXCR4 and CCR5 expression on circulating T cells were studied in 30 house dust mite sensitive-patients with allergic diseases and in another 30 healthy controls. The expression was analyzed in CD4, CD8 and double negative (DN) T cells by triple fluorescence staining. In addition, intracellular cytokine staining was performed in the CCR3+ CD4+ T cells. Increased circulating portions of CCR3+ CD4+ T cells and CCR3+ DN T cells were found in these patients (p < 0.01). There was no statistically significant difference in the expression of CXCR4 and CCR5 on T cells. The follow-up data of the patients did not show a statistically significant change in the CCR3 expression. IL-4 was expressed within CCR3+ CD4+ T cells upon activation. The IL-4 secreting CCR3+ type 2 T helper cells may play a pathogenetic role in immune responses of house dust mite-sensitive Chinese patients with allergic diseases.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Taiwan / Female / Humans / Male / CD4-Positive T-Lymphocytes / Adolescent / Interleukin-4 / Th2 Cells / Adult / Receptors, Chemokine Country/Region as subject: Asia Language: English Journal: Asian Pac J Allergy Immunol Year: 2003 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Taiwan / Female / Humans / Male / CD4-Positive T-Lymphocytes / Adolescent / Interleukin-4 / Th2 Cells / Adult / Receptors, Chemokine Country/Region as subject: Asia Language: English Journal: Asian Pac J Allergy Immunol Year: 2003 Type: Article