What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study
Gut and Liver
;
: 576-584, 2013.
Article
in English
| WPRIM
| ID: wpr-103738
ABSTRACT
BACKGROUND/AIMS:
The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion therapy for hepatocellular carcinoma (HCC).METHODS:
We divided 13 HCC patients into the following three groups group A, lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gelatin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes.RESULTS:
The mean free cisplatin concentrations were as follows. For group A, the mean was 48.58 microg/mL at 0 minute, 7.31 microg/mL at 5 minutes, 5.70 microg/mL at 10 minutes, and 7.15 microg/mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65 microg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 microg/mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27 in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C.CONCLUSIONS:
These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pilot Projects
/
Drainage
/
Cisplatin
/
Drug Delivery Systems
/
Ethiodized Oil
/
Carcinoma, Hepatocellular
/
Gelatin
/
Hepatic Veins
/
Liver
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2013
Type:
Article
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