Ratio of M1/M2 macrophages in pleural effusion and prognosis in patients with tuberculous pleurisy / 中国现代医生

ABSTRACT

Objective To analyze the relationship between the proportion of M1/M2 macrophages in mononuclear cells of patients with tuberculous pleurisy(TP)and the prognosis of TP.Methods A total of 206 TP patients admitted from June 2019 to December 2022 were selected,and their M1 and M2 mononuclear macrophages were detected at admission.Single factor and logistic regression were used to analyze the risk factors affecting the prognosis of TP,and the predictive value of M1/M2 monocyte macrophage ratio on the poor prognosis of TP was evaluated by the receiver operating characteristic curve(ROC).Results Logistic analysis showed that the time from onset to visit,infection resistant bacteria,expression level of ESR,M1 and M2 macrophages,and ratio of M1/M2 macrophages were risk factors for poor prognosis of TP patients(P<0.05).The area under the curve(AUC)of M1 and M2 macrophage expression level predicting poor prognosis of TP patients were 0.783 and 0.829,respectively,with sensitivity of 70.45%and 81.47%,and specificity of 79.62%and 73.44%,respectively.The AUC of M1/M2 macrophage ratio predicting poor prognosis of TP patients was 0.921,sensitivity of 92.59%,and specificity of 84.96%,which were significantly higher than those predicted by the two alone(P<0.05).Conclusion The time from onset to treatment,the infection of drug-resistant bacteria,the expression level of ESR,M1 and M2 macrophages,and the ratio of M1/M2 macrophages are the risk factors that affect the poor prognosis of TP patients,and the ratio of M1/M2 macrophages has a high predictive value for the poor prognosis of TP patients.