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Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan
Intestinal Research ; : 139-145, 2016.
Article in English | WPRIM | ID: wpr-111593
ABSTRACT
BACKGROUND/

AIMS:

Anti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy. However, there are limited data on the benefit/risk profile of anti-TNF and thiopurines during pregnancy in Asia. The aim of this study was to analyze pregnancy outcomes of female Japanese IBD patients treated with anti-TNF and/or thiopurines.

METHODS:

This cross-sectional study assessed pregnancy outcomes in 72 women with IBD. Pregnancy outcomes were compared among 31 pregnancies without exposure to infliximab (IFX), adalimumab (ADA), or thiopurines; 24 pregnancies with exposure to anti-TNF treatment (23 IFX, 1 ADA); 7 pregnancies with exposure to thiopurines alone; and 10 pregnancies with exposure to both IFX and thiopurines.

RESULTS:

Thirty-five of the 41 pregnancies (85.3%) that were exposed to anti-TNF treatment and/or thiopurines resulted in live births after a median gestational period of 38 weeks. Of the 35 live births, 3 involved premature deliveries; 7, low birth weight; and 1, a congenital abnormality. There were 6 spontaneous abortions in pregnancies that were exposed to anti-TNF treatment (17.7%). Pregnancy outcomes among the 4 groups were similar, except for the rate of spontaneous abortions (P =0.037).

CONCLUSIONS:

Exposure to anti-TNF treatment or thiopurines during pregnancy was not related to a higher incidence of adverse pregnancy outcomes in Japanese IBD patients except for spontaneous abortion.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Asia / Congenital Abnormalities / Infant, Low Birth Weight / Pregnancy Outcome / Inflammatory Bowel Diseases / Abortion, Spontaneous / Incidence / Cross-Sectional Studies / Asian People / Live Birth Type of study: Controlled clinical trial / Incidence study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: Intestinal Research Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Asia / Congenital Abnormalities / Infant, Low Birth Weight / Pregnancy Outcome / Inflammatory Bowel Diseases / Abortion, Spontaneous / Incidence / Cross-Sectional Studies / Asian People / Live Birth Type of study: Controlled clinical trial / Incidence study / Observational study / Prevalence study / Prognostic study / Risk factors Limits: Female / Humans / Infant, Newborn / Pregnancy Country/Region as subject: Asia Language: English Journal: Intestinal Research Year: 2016 Type: Article