Preliminary Study on Neurodevelopmental Outcome and Placental Pathology among Extremely Low Birth Weight Infants / 대한주산의학회잡지
Korean Journal of Perinatology
; : 67-77, 2015.
Article
in Ko
| WPRIM
| ID: wpr-118866
Responsible library:
WPRO
ABSTRACT
PURPOSE: To investigate the relationship between placental pathology and neurodevelopmental outcomes among extremely low birth weight (ELBW) infants. METHODS: Pathology of placentas from ELBW infants born at a tertiary neonatal intensive care unit from January 2007 to December 2012 were reviewed and placental histology was grouped into 3 categories by a designated pathologist: acute chorioamnionitis (ACA), maternal vascular underperfusion (MVU), and control group. Matched ELBW infants were tested for significant neurodevelopmental delays defined as mental developmental index (MDI) or psychomotor developmental index (PDI) <70, using Bayley Scales of Infant Development-II (BSID-II). RESULTS: The mean gestational age and birth weight of 175 infants were 27.1+/-2.5 weeks and 764.7+/-152.3 g respectively. Placental histology revealed MVU (48.0%), ACA (25.1%) and control (26.9%) in distribution. There were less significant patent ductus arteriosus in MVU group than in control group [adjusted odds ratio (OR)=0.331, P=0.011]. The frequencies of other neonatal diseases and mortality were similar in 3 groups. Sixty four of 175 infants were examined for BSID-II at mean corrected 19.9+/-3.2 months. MVU was associated with significant mental developmental delay (OR=5.185, P=0.036), but after adjustment for head circumference/weight at birth, the statistically significance of association disappeared (adjusted OR=4.391, P=0.075). ACA did not affect neonatal and neurodevelopmental outcomes. CONCLUSION: The result of placenta biopsy could be a useful tool in counseling parents for future neurodevelopmental outcome, however, further studies are required to define definitive association in between placenta biopsy and neurodevelopmental outcomes.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Parents
/
Pathology
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Placenta
/
Weights and Measures
/
Biopsy
/
Birth Weight
/
Infant, Low Birth Weight
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Intensive Care, Neonatal
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Odds Ratio
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Mortality
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Female
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Humans
/
Infant
/
Newborn
/
Pregnancy
Language:
Ko
Journal:
Korean Journal of Perinatology
Year:
2015
Type:
Article