Identification of Lymph Node Micrometastases in Dukes' B Colorectal Cancer Patients Using Monoclonal Antibodies against Cytokeratin-19
Journal of the Korean Surgical Society
;
: 385-390, 2004.
Article
in Korean
| WPRIM
| ID: wpr-133518
ABSTRACT
PURPOSE:
The aims of this study were to immunohistochemically identify lymph node micormetastases in Dukes' B colorectal cancer patients, and determine the relationship between lymph node micrometastases and other prognostic factors and recurrence rates.METHODS:
A retrospective analysis was conducted of 990 lymph nodes from Dukes' B 42 patients who had undergone radical colorectal resection. These lymph nodes were immunohistochemically examined with monoclonal antibodies against cytokeratin-19. The prognostic factors and recurrent rates were compared between patients with and without lymph node micrometastases.RESULTS:
Micrometastases were confirmed in 19 nodes (1.9%) from 9 patients (21.4%). No correlations were observed between micrometastases and the prognostic factors, with the exception of the preoperative CEA level. 8 of the 9 (88.9%) patients with micrometastases had preoperative CEA levels significantly elevated above 5 ng/ml (P<0.0001). There were no significant differences in the recurrent rates (P=0.0572) between patients with and without micrometastases during the short term follow up period (14.8 months) at the 95% confidence interval, but there were significant differences at the 90% confidence interval.CONCLUSION:
High preoperative CEA levels increase the risk for micrometastases, and the presence of micrometastases might increase the possibility of recurrence. Thus, a routine immunohistochemical technique for identifying micrometastases is recommended in the patients with a high preoperative CEA level. However, a more definite clinical significance of lymph node micrometastases awaits further extensive prospective studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Colorectal Neoplasms
/
Retrospective Studies
/
Follow-Up Studies
/
Keratin-19
/
Neoplasm Micrometastasis
/
Lymph Nodes
/
Antibodies, Monoclonal
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Surgical Society
Year:
2004
Type:
Article
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