Serum Levels of IL-8 and ICAM-1 as Biomarkers for Progressive Massive Fibrosis in Coal Workers' Pneumoconiosis
Journal of Korean Medical Science
; : 140-144, 2015.
Article
in En
| WPRIM
| ID: wpr-141166
Responsible library:
WPRO
ABSTRACT
Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1alpha (MIP-alpha), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) in 106 subjects (27 non-CWP and 79 CWP patients). The levels of serum IL-8 (P<0.001) and ICAM-1 (P=0.001) of subjects with PMF were higher than those of non-CWP subjects. The IL-8 levels of PMF subjects were also higher than those of simple CWP subjects (P=0.003). Among the subjects without PMF, IL-8 levels in the subjects with International Labour Organization (ILO) category II or III were higher than those in the subjects with ILO category 0 (P=0.006) and with category I (P=0.026). These results suggest that high serum levels of IL-8 and ICAM-1, which are important as neutrophil attractants and adhesion molecules, are associated with PMF.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Pulmonary Fibrosis
/
Biomarkers
/
Interleukin-8
/
Coal Mining
/
Intercellular Adhesion Molecule-1
/
Chemokine CCL3
/
Anthracosis
/
Lung
/
Occupational Diseases
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2015
Type:
Article