Intron 4 VNTR (4a/b) Polymorphism of the Endothelial Nitric Oxide Synthase Gene Is Associated with Breast Cancer in Mexican Women
Journal of Korean Medical Science
; : 1587-1594, 2013.
Article
in En
| WPRIM
| ID: wpr-148472
Responsible library:
WPRO
ABSTRACT
The endothelial nitric oxide synthase (eNOS) gene plays an important role in several biological functions. Polymorphisms of the eNOS gene have been associated with cancer. It has been suggested that the VNTR 4 a/b polymorphism may affect the expression of eNOS and contributes to tumor promotion in the mammary gland. We examined the role of the eNOS4 a/b polymorphism by comparing the genotypes of 281 healthy Mexican women with the genotypes of 429 Mexican women with breast cancer (BC). The observed genotype frequencies for control and BC patients were 0.6% and 0.7% for a/a (polymorphic); 87% and 77% for a/a (wild type); and 12% and 22% for a/b respectively. We found that the odds ratio (OR) was 1.9, with a 95% confidence interval (95%CI) of 1.29-2.95, P = 0.001 for genotypes a/a-a/b, b/c. The association was also evident when comparing the distribution of the a/a-a/b genotypes in patients with high levels of glutamate-oxaloacetate transaminase (SGOT) (OR, 1.93; 95% CI, 1.14-3.28; P = 0.015); undergoing menopause with high levels of SGOT (OR, 2.0; 95% CI, 1.1-3.84); and with high levels of glutamic-pyruvic transaminase (SGPT) (OR, 3.5; 95% CI, 1.56-8.22). The genotypes a/a-a/b are associated with BC susceptibility in the analyzed samples from the Mexican population.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Aspartate Aminotransferases
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Breast Neoplasms
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Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
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Alanine Transaminase
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Nitric Oxide Synthase Type III
/
Gene Frequency
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Genotype
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Mexico
/
Nitric Oxide
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
Mexico
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article