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The Renal Function and the Preoperative Predictive Factors Influencing Renal Function after Living Donor Nephrectomy / 대한비뇨기과학회지
Korean Journal of Urology ; : 149-157, 2004.
Article in Korean | WPRIM | ID: wpr-148823
ABSTRACT

PURPOSE:

The aim of this study is to identify postoperative renal function and preoperative factors that can predict renal impairment after living donor nephrectomy. MATERIALS AND

METHODS:

We studied 172 patients undergoing living donor nephrectomy for kidney transplantation (115 males, 57 females). We analyzed the renal function measured by serum creatinine and the 99mTc- diethylenetriamine penta-acetic acid (DTPA) renal scan. Using a univariate and multivariate analysis, we also analyzed multiple independent variables for the remaining renal function following living donor nephrectomy, such as serum creatinine, glomerular filtration rate (GFR), age, sex, duration of follow-up, blood pressure, body mass index (BMI), serum calcium, serum phosphate, serum uric acid.

RESULTS:

The mean age of the donors was 34 years, and the mean duration of the follow-ups was 11 months. The mean serum creatinine at 11 months after kidney donation was increased compared to preoperative creatinine (1.26mg/dl vs. 0.93mg/dl), and significantly greater in the males than in the females (1.36mg/dl vs. 1.09mg/dl). Mean GFR measured by the 99mTc- DTPA renal scan at 11 months after kidney donation was 69.2 ml/min/ 1.73m2 and similar for men and women (72.3ml/min/1.73m2 vs. 68.3ml/ min/1.73m2). The univariate analysis showed that preoperative creatinine was significantly associated with postoperative creatinine only (p<0.001), and age and sex were associated with the change in creatinine (p=0.046, p<0.001). The univariate analysis also showed that preoperative GFR and age were significantly associated with postoperative GFR (p<0.001, p<0.001), and age was associated with compensatory change in GFR (p= 0.008). The multivariate analysis showed that preoperative GFR was the primary predictive factor of postoperative GFR (r=0.73, p<0.001), and age was an independent secondary predictive factor (r= 0.67, p<0.001).

CONCLUSIONS:

These results suggest that postoperative renal function has been preserved in kidney donors, and preoperative creatinine, preoperative GFR, and age at donation were the important predictive factors of renal function after living donor nephrectomy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Uric Acid / Blood Pressure / Body Mass Index / Calcium / Multivariate Analysis / Follow-Up Studies / Kidney Transplantation / Living Donors / Creatinine Type of study: Observational study / Prognostic study Limits: Female / Humans / Male Language: Korean Journal: Korean Journal of Urology Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Uric Acid / Blood Pressure / Body Mass Index / Calcium / Multivariate Analysis / Follow-Up Studies / Kidney Transplantation / Living Donors / Creatinine Type of study: Observational study / Prognostic study Limits: Female / Humans / Male Language: Korean Journal: Korean Journal of Urology Year: 2004 Type: Article