Immunogenicity and Safety of Diphtheria-tetanus Vaccine in Adults
Journal of Korean Medical Science
; : 1727-1732, 2010.
Article
in En
| WPRIM
| ID: wpr-15542
Responsible library:
WPRO
ABSTRACT
This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and tetanus, respectively, which were below protective level ( or =0.1 U/mL) for diphtheria and tetanus, with an increase to 99.6% and 100% after the third dose. Local and systemic adverse events occurred in 37.9% and 15.5% of the subjects. No serious adverse event requiring an unscheduled hospital visit occurred. In conclusion, three-doses of Td vaccination to unimmunized adults are safe and effective in inducing protective immunity against diphtheria and tetanus.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Tetanus
/
Tetanus Toxoid
/
Immunization, Secondary
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Diphtheria-Tetanus Vaccine
/
Diphtheria
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Antibodies, Bacterial
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2010
Type:
Article