A Case of Myeloid Neoplasm with a PDGFRB Rearrangement and Eosinophilia / 대한내과학회지
Korean Journal of Medicine
; : 79-83, 2017.
Article
in Ko
| WPRIM
| ID: wpr-155824
Responsible library:
WPRO
ABSTRACT
Myeloid neoplasia with eosinophilia and platelet-derived growth factor receptor beta (PDGFRB) rearrangements is an uncommon Philadelphia-negative myeloproliferative neoplasm. Their most common morphological diagnosis is chronic myelomonocytic leukemia with eosinophilia, which is associated with t(5;12)(q33;p13) and results in the formation of the ETV6-PDGFRB fusion gene. Here, we report a 49-year-old man with a myeloid neoplasm with a PDGFRB rearrangement, who was incidentally diagnosed with hyperleukocytosis and eosinophilia during a health screening. A chromosome analysis of a bone marrow sample revealed 46, XY, t(5;12)(q33;p13), and fluorescence in situ hybridization analysis revealed the PDGFRB gene rearrangement. The patient was treated with imatinib and subsequently achieved complete hematological and molecular remission.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Bone Marrow
/
Gene Rearrangement
/
Leukemia, Myelomonocytic, Chronic
/
Mass Screening
/
Receptors, Platelet-Derived Growth Factor
/
In Situ Hybridization
/
Receptor, Platelet-Derived Growth Factor beta
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Diagnosis
/
Eosinophilia
/
Fluorescence
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limits:
Humans
Language:
Ko
Journal:
Korean Journal of Medicine
Year:
2017
Type:
Article