Effects of Add-on Ramelteon on Cognitive Impairment in Patients with Schizophrenia: An Open-label Pilot Trial
Clinical Psychopharmacology and Neuroscience
;
: 215-217, 2014.
Article
in English
| WPRIM
| ID: wpr-171397
ABSTRACT
OBJECTIVE:
This open-label study examined the effects of ramelteon on cognitive functions in 10 outpatients with schizophrenia.METHODS:
Ramelteon (8 mg/day) was administered to 10 patients with schizophrenia for six months. The verbal fluency test, Trail-Making Test, the Wisconsin Card Sorting Test, the Stroop Test, the Digit Span Distraction Test, Iowa Gambling Task, the Rey Auditory Verbal Learning Test were evaluated at baseline and 6 months after treatment with ramelteon.RESULTS:
Ramelteon improved significantly the scores of Rey Auditory Verbal Learning Test. Additionally, ramelteon exerted improvements in the verbal fluency and Iowa Gambling Task in 4 patients.CONCLUSION:
Ramelteon could be a potential therapeutic drug, in adjunctive treatment of learning and memory deficits seen in patients with schizophrenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Schizophrenia
/
Verbal Learning
/
Wisconsin
/
Iowa
/
Stroop Test
/
Gambling
/
Learning
/
Memory Disorders
Limits:
Humans
Country/Region as subject:
North America
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2014
Type:
Article
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