Systematic Review and Meta-Analysis of Pulmonary Hypertension Specific Therapy for Exercise Capacity in Chronic Obstructive Pulmonary Disease
Journal of Korean Medical Science
;
: 1200-1206, 2013.
Article
in English
| WPRIM
| ID: wpr-173135
ABSTRACT
Some patients with chronic obstructive pulmonary disease (COPD) have pulmonary hypertension (PH) that adversely affects survival. We performed a systematic review and meta-analysis to assess whether PH-specific therapies have an effect for stable COPD. Data sources were Medline, EMBASE, Cochrane Central Register of Controlled Trials, Korea med and references from relevant publications. Randomized prospective trials that compared PH specific therapy in COPD for more than 6 weeks with placebo were included. The outcomes were the exercise capacity and adverse events. Four randomized controlled trials involving 109 subjects were included in the analysis. Two trials involved bosentan, one sildenafil and one beraprost. The studies varied in duration of treatment from 3 to 18 months. In a pooled analysis of four trials, exercise-capacity was not significantly improved with PH-specific treatment for COPD (risk ratio, -5.1; 95% CI, -13.0 to 2.8). COPD with overt PH significantly improved the exercise capacity (mean difference, 111.6; 95% CI, 63.3 to 159.9) but COPD with PH unknown did not (mean difference, 26.6; 95% CI, -24.3 to 77.5). There was no significant difference in hypoxemia (mean difference, 2.6; 95% CI, -3.7 to 8.8). PH specific treatments have a significant effect in improving exercise capacity in COPD with overt PH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperazines
/
Purines
/
Sulfonamides
/
Sulfones
/
Surveys and Questionnaires
/
Risk Factors
/
Clinical Trials as Topic
/
Databases, Factual
/
Epoprostenol
/
Pulmonary Disease, Chronic Obstructive
Type of study:
Controlled clinical trial
/
Etiology study
/
Risk factors
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article
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