Intravenous albumin for the prevention of contrast-induced nephropathy in patients with liver cirrhosis and chronic kidney disease undergoing contrast-enhanced CT
Kidney Research and Clinical Practice
; : 106-111, 2012.
Article
in En
| WPRIM
| ID: wpr-174799
Responsible library:
WPRO
ABSTRACT
BACKGROUND: The purpose of this study was to evaluate the incidence of contrast-induced nephropathy (CIN), and the effect of intravenous albumin for prophylaxis of CIN in patients with liver cirrhosis (LC) and chronic kidney disease (CKD). METHODS: We conducted a retrospective study of 81 subjects with LC and CKD (estimated glomerular filtration rate (eGFR) or =25% or > or =0.5mg/dL in serum creatinine level. RESULTS: Overall, CIN developed in three patients (3.7%). Of the 81 subjects, 43 received sodium bicarbonate solution and 38 received albumin. Both groups were comparable with regard to age, sex, diabetes mellitus, and baseline eGFR. The albumin group showed a significantly poorer liver function profile. CIN incidence did not differ significantly between the groups: it occurred in one (2.3%) of the 43 subjects receiving sodium bicarbonate and two (5.3%) of the 38 subjects receiving albumin (P=0.6). However, the albumin group showed a significantly smaller increase in body weight (P=0.03). CONCLUSION: The incidence of CIN in patients with LC and CKD undergoing contrast-enhanced CT after preventive measures was relatively low. The incidence of CIN was not significantly different between sodium bicarbonate and albumin groups.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Body Weight
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Incidence
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Retrospective Studies
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Sodium Bicarbonate
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Creatinine
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Diabetes Mellitus
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Renal Insufficiency, Chronic
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Glomerular Filtration Rate
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Liver
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Liver Cirrhosis
Type of study:
Incidence_studies
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Observational_studies
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Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Kidney Research and Clinical Practice
Year:
2012
Type:
Article