Anti-TNF-alpha Therapy for Ankylosing Spondylitis
Clinics in Orthopedic Surgery
; : 28-33, 2010.
Article
in En
| WPRIM
| ID: wpr-192615
Responsible library:
WPRO
ABSTRACT
BACKGROUND: This review evaluated the safety and efficacy of etanercept in patients with ankylosing spondylitis (AS). METHODS: Of 59 patients with AS, this study reviewed 11 patients who were refractory to conventional therapy and treated with etanercept from September 2005 to January 2008. The mean follow-up duration was 13.6 months. The general improvement was evaluated by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), and adverse effects, complications and inflammatory markers were also assessed. RESULTS: The mean BASDAI decreased from 7.1 +/- 1.6 before treatment to 4.2 +/- 1.8 at 3 months after the etanercept treatment (p = 0.001). The mean erythrocyte sedimentation rate and C-reactive protein were decreased significantly by the etanercept treatment. The greatest improvement in symptoms was enthesitis, followed by skin involvement and morning stiffness. There was a significant difference in the improvement in BASDAI along with the follow up duration (p = 0.04). A serious infection was observed as a complication in 1 case. CONCLUSIONS: These results suggest that etanercept can induce significant improvement in most patients with less damage. A trial of tumor necrosis factor inhibition is indicated in all AS patients who do not achieve adequate disease control with disease-modifying antirheumatic drugs, such as methotrexate, leflunomide etc. The patients treated with etanercept should be educated about the possibility of infection and monitored closely.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Spondylitis, Ankylosing
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Blood Sedimentation
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C-Reactive Protein
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Immunoglobulin G
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Drug Administration Schedule
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Anti-Inflammatory Agents, Non-Steroidal
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Tumor Necrosis Factor-alpha
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Receptors, Tumor Necrosis Factor
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Antirheumatic Agents
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Injections, Subcutaneous
Limits:
Adult
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Female
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Humans
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Male
Language:
En
Journal:
Clinics in Orthopedic Surgery
Year:
2010
Type:
Article