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Alpha Internexin Expression Related with Molecular Characteristics in Adult Glioblastoma and Oligodendroglioma
Article in En | WPRIM | ID: wpr-194142
Responsible library: WPRO
ABSTRACT
Alpha-internexin (INA) is a proneuronal gene-encoding neurofilament interacting protein. INA is overexpressed mostly in oligodendroglial phenotype gliomas, is related to 1p/19q codeletion, and is a favorable prognostic marker. We studied INA expression in oligodendrogliomas (ODGs) and glioblastomas (GBMs) to verify its association with several molecular phenotypes, 1p/19q codeletion, and epidermal growth-factor-receptor (EGFR) amplification. A total of 230 low- and high-grade ODG and GBM cases was analyzed for INA expression by immunohistochemical staining; and 1p/19q and EGFR gene status was examined by fluorescence in-situ hybridization. INA was positive in 80.3% of ODGs and in 34.3% of GBMs. 1p/19q codeletion was detected in 77.0% of ODGs and 5.5% of GBMs. INA and 1p/19q codeletion were strongly correlated (P < 0.001). The specificity of INA expression for 1p/19q codeletion was 70.8%, while sensitivity was 100%; positive predictive value was 72.5%, and negative predictive value was 29.2% in all 228 tumors. INA expression was correlated with better progression-free survival (PFS) and overall survival (OS) (P = 0.001). In conclusion, INA expression has high specificity and sensitivity to predict 1p/19q codeletion, and it is well correlated with PFS of both ODGs and GBMs. Therefore, INA expression could be a simple, reliable, and favorable prognostic and surrogate marker for 1p/19q codeletion and long term survival.
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Full text: 1 Index: WPRIM Main subject: Oligodendroglioma / Phenotype / Prognosis / Chromosomes, Human, Pair 1 / Chromosomes, Human, Pair 19 / Brain Neoplasms / Immunohistochemistry / Predictive Value of Tests / In Situ Hybridization, Fluorescence / Gene Deletion Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Journal of Korean Medical Science Year: 2013 Type: Article
Full text: 1 Index: WPRIM Main subject: Oligodendroglioma / Phenotype / Prognosis / Chromosomes, Human, Pair 1 / Chromosomes, Human, Pair 19 / Brain Neoplasms / Immunohistochemistry / Predictive Value of Tests / In Situ Hybridization, Fluorescence / Gene Deletion Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Journal of Korean Medical Science Year: 2013 Type: Article