Alpha Internexin Expression Related with Molecular Characteristics in Adult Glioblastoma and Oligodendroglioma
Journal of Korean Medical Science
; : 593-601, 2013.
Article
in En
| WPRIM
| ID: wpr-194142
Responsible library:
WPRO
ABSTRACT
Alpha-internexin (INA) is a proneuronal gene-encoding neurofilament interacting protein. INA is overexpressed mostly in oligodendroglial phenotype gliomas, is related to 1p/19q codeletion, and is a favorable prognostic marker. We studied INA expression in oligodendrogliomas (ODGs) and glioblastomas (GBMs) to verify its association with several molecular phenotypes, 1p/19q codeletion, and epidermal growth-factor-receptor (EGFR) amplification. A total of 230 low- and high-grade ODG and GBM cases was analyzed for INA expression by immunohistochemical staining; and 1p/19q and EGFR gene status was examined by fluorescence in-situ hybridization. INA was positive in 80.3% of ODGs and in 34.3% of GBMs. 1p/19q codeletion was detected in 77.0% of ODGs and 5.5% of GBMs. INA and 1p/19q codeletion were strongly correlated (P < 0.001). The specificity of INA expression for 1p/19q codeletion was 70.8%, while sensitivity was 100%; positive predictive value was 72.5%, and negative predictive value was 29.2% in all 228 tumors. INA expression was correlated with better progression-free survival (PFS) and overall survival (OS) (P = 0.001). In conclusion, INA expression has high specificity and sensitivity to predict 1p/19q codeletion, and it is well correlated with PFS of both ODGs and GBMs. Therefore, INA expression could be a simple, reliable, and favorable prognostic and surrogate marker for 1p/19q codeletion and long term survival.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Oligodendroglioma
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Phenotype
/
Prognosis
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Chromosomes, Human, Pair 1
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Chromosomes, Human, Pair 19
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Brain Neoplasms
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Immunohistochemistry
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Predictive Value of Tests
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In Situ Hybridization, Fluorescence
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Gene Deletion
Type of study:
Prognostic_studies
Limits:
Adult
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Female
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Humans
/
Male
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article