Optimization of Extraction Conditions for Active Compounds of Herbal Medicinal Formula, DF, by Response Surface Methodology
Natural Product Sciences
;
: 9-15, 2017.
Article
in English
| WPRIM
| ID: wpr-198628
ABSTRACT
DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in Korea. We tried to optimize the extraction conditions of two major components, (−)-ephedrine and (+)-pseudoephedrine, in DF formula using response surface methodology with Box-Behnken design (BBD). The experimental conditions with 70% for EtOH concentrations, 4.8 hour for extraction hours and 8.7 times for the solvent to material ratio were suggested for the optimized extraction of DF formula with the highest amounts of (−)-ephedrine and (+)-pseudoephedrine in the designed model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rheum
/
Chromatography, High Pressure Liquid
/
Lithospermum
/
Ephedra
/
Korea
/
Metabolic Diseases
/
Obesity
Country/Region as subject:
Asia
Language:
English
Journal:
Natural Product Sciences
Year:
2017
Type:
Article
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