Your browser doesn't support javascript.
loading
The Effect of Anti-reflux Therapy on Patients Diagnosed with Minor Disorders of Peristalsis in High-resolution Manometry / 대한소화기학회지
The Korean Journal of Gastroenterology ; : 212-219, 2017.
Article in English | WPRIM | ID: wpr-199026
ABSTRACT
BACKGROUND/

AIMS:

Minor disorders of peristalsis are esophageal motility disorders categorized by the Chicago Classification (CC), version 3.0, which was announced in 2014. This study evaluated the efficacy of anti-reflux therapy in patients with minor peristaltic disorders.

METHODS:

Patients with minor peristaltic disorders in accordance with CC v3.0 were included. We reviewed the medical records of patients with esophageal high-resolution manometry findings, and investigated the demographic and clinical information as well as the medical therapy. Thereafter, the response to treatment was assessed after at least 4 weeks of treatment.

RESULTS:

A total of 24 patients were identified as having minor disorders of peristalsis from January 2010 to December 2015. The mean follow-up period was 497 days, and there were 17 patients (70.8%) patients with ineffective esophageal motility. In terms of anti-reflux therapy, proton pump inhibitors (PPIs) with prokinetic agents and PPIs alone were prescribed in 19 patients (79.2%) and 5 patients (20.8%), respectively. When the rate of response to the treatment was assessed, the responders rate (complete+satisfactory [≥50%] responses) was 54.2% and the non-responders rate (partial [<50%]+refractory responses) was 45.8%. Patients in the responder group were younger than those in the non-responder group (p=0.020). Among them, 13 patients underwent 24-hour multichannel intraluminal impedance-pH, and 10 patients (76.9%) were pathologic gastroesophageal reflux.

CONCLUSIONS:

The majority of esophageal minor peristaltic disorders were accompanied by gastroesophageal reflux, and therefore, they might respond to acid inhibitor. Further well-designed, prospective studies are necessary to confirm the effect of anti-reflux therapy in these patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Peristalsis / Esophageal Motility Disorders / Gastroesophageal Reflux / Medical Records / Prospective Studies / Follow-Up Studies / Treatment Outcome / Classification / Proton Pump Inhibitors / Proton Therapy Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: The Korean Journal of Gastroenterology Year: 2017 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Peristalsis / Esophageal Motility Disorders / Gastroesophageal Reflux / Medical Records / Prospective Studies / Follow-Up Studies / Treatment Outcome / Classification / Proton Pump Inhibitors / Proton Therapy Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: English Journal: The Korean Journal of Gastroenterology Year: 2017 Type: Article