Interaction between Causative Factors of Cervical Cancer and BARD-1 (BRCA-associated ring domain-1) Polymorphism / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 1698-1707, 2005.
Article
in Ko
| WPRIM
| ID: wpr-205143
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: The aim of this study was to identify interaction between causative factors of cervical cancer and BARD-1 (BRCA1 associated ring domain-1) polymorphism on cervical carcinogenesis in Korean women. METHODS: We evaluated 1,347 patients composed of women who had cervical cancer (n=337) and cervical intraepithelial neoplasia (n=308) and normal control healthy women (n=702) from October 2000 until November 2001. The single nucleotide polymorphisms (SNPs) of BARD-1 were evaluated from extracted DNA of peripheral blood with automatic DNA sequencer. The difference of each SNP between normal controls and patients was evaluated in the adjusted environmental background. RESULTS: In environmental aspect, the cervical cancer increased in the women who had the lower level of education, smoking history, the younger age of the first sexual intercourse, and the more child-bearing . The women who had BARD V507M (Arg/Arg) showed 1.6 fold increased risk in cervical cancer than the women who had BARD V507M (G/G), (G/A)(p=0.0433). And the risk increased with BARD R378S (C/C) among who have environmental risk factors compared with BARD R378S (G/G), (G/C) allele positive who have no environmental risk factors. CONCLUSION: We found that the level of education, the age at first intercourse, and the number of children were the independent risk factors in cervical carcinogenesis. The specific combination of BARD-1 and gene-environmental interactions were significantly noted in the cervical carcinogenesis in Korean women.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Smoke
/
DNA
/
Smoking
/
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
Risk Factors
/
Coitus
/
Polymorphism, Single Nucleotide
/
Education
/
Alleles
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Female
/
Humans
Language:
Ko
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article