Validity of MAST-CLA for diagnosis of arthropod allergy using receiver operating characteristic (ROC) analysis
The Korean Journal of Parasitology
; : 239-243, 2007.
Article
in En
| WPRIM
| ID: wpr-219735
Responsible library:
WPRO
ABSTRACT
Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MAST-CLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and k-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Skin Tests
/
Allergens
/
ROC Curve
/
Cockroaches
/
Insect Proteins
/
Dermatophagoides farinae
/
Dermatophagoides pteronyssinus
/
Antigens, Dermatophagoides
/
Hypersensitivity
/
Luminescent Measurements
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
The Korean Journal of Parasitology
Year:
2007
Type:
Article